Effects of drugs of abuse and scopolamine on memory in rats: delayed spatial alternation and matching to position |
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Authors: | S P Baron Dean Wright G R Wenger |
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Institution: | (1) Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, MS 611, 4301 W. Markham Street, Little Rock, AR 72205-7199, USA, US |
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Abstract: | Drugs of abuse produce amnestic effects in humans and laboratory animals in a variety of tasks. Generally, only a few compounds
have been examined in any particular procedure. It was the goal of the present studies to examine drugs of abuse of different
pharmacological classes in rats responding under two behavioral schedules historically employed as experimental models of
memory: spatial alternation and matching to position. One group of rats responded under a single-response spatial-alternation
baseline with a 10-s delay and another group responded under a matching-to-position baseline with delay values of 3, 10 and
30 s. Performance under the spatial-alternation baseline was characterized by low variability and >90% accuracy. Under the
matching-to-position baseline, saline control percent accuracy was >95% at 3 s, >85% at 10 s and >70% at 30 s. Under spatial
alternation cocaine, d-amphetamine, pentobarbital, diazepam, phencyclidine, scopolamine and methscopolamine produced significant (P<0.05) effects on accuracy, whereas only cocaine, d-amphetamine, pentobarbital and phencyclidine disrupted accuracy under the matching-to-position baseline. These results suggest
that spatial alternation may be a more sensitive baseline for determining drug effects on working memory in the rat.
Received: 16 April 1997 / Final version: 25 November 1997 |
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Keywords: | Memory Rats Spatial alternation Matching to position Drugs of abuse |
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