An enucleated duodenal gastrinoma with multiple type 1 endocrine neoplasia located by selective arterial calcium injection |
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Authors: | Shoji Hirokazu Kuroki Michio Nakano Eriko Hiramoto Keiichiro Matsumura Yoshifumi Miura Atsushi Kikuchi Yoshifumi Hirakawa Hidetoshi Matsuda Mikio |
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Institution: | Department of Gastroenterology, Yamagata City Hospital Saiseikan. hshouji@ncc.go.jp |
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Abstract: | We report a duodenal gastrinoma in a 50-year-old man who was admitted to our hospital with tarry stools. Esophagogastroduodenoscopy revealed multiple ulcers in the duodenal bulb and a submucosal tumor in the descending duodenum. His serum gastrin level was 1400pg/ml. We suspected Zollinger-Ellison syndrome and performed selective arterial calcium injection to locate the gastrinoma. Increase in the hepatic venous gastrin level was seen only in the gastroduodenal artery area. We diagnosed a gastrinoma located in the pancreaticoduodenal area. Genetic examination showed a single-base deletion in the MEN-1 gene. At operation, the tumor was found in the submucosal layer of the descending duodenum and was extirpated. He is alive without recurrence 3 years after surgery. |
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