血清CA125、CA199和SIL-2R联检在EMS中的诊断价值探讨

目的:探讨了血清CA125、CA199及SIL-2R联检对EMS的诊断价值。方法:应用放免法和ELISA法分别对54例EMS患者进行了血清CA125、CA199及SIL-2R水平测定,并与35名正常健康人作比较。结果:EMS患者血清中CA125、CA199及SIL-2R水平非常显著地高于正常人组(P<0.01)。EMS患者血清中CA125敏感性和特异性分别为70.2%和80.4%,CA199敏感性和特异性分别为62.4%和71.8%。SIL-2R的敏感性为89.5%,特异性为60.2%。CA125和CA199、SIL-2R联检的敏感性提高到了86.8%,除SIL-2R敏感性外与其它两者单独测定的敏感度有显著性差异(P<0.01)。结论:血清CA125、CA199及SIL-2R联检能提高EMS诊断的敏感度,有一定的临床价值。

Study on the Diagnostic Value of Combined Determination of Serum CA125,CA199 and SIL-2R Levels in Patients with Endometriosis

Objective To investigate the diagnostic values of combined determination of serum CA125, CA199 and SIL-2R levels in patients with endometriosis. Methods Serum CA125, CA199 were measured with RIA and SIL-2R levels with ELISA in 54 patients with endometriosis and 35 controls. Results The serum levels of CA125, CA199 and SIL-2R in patients with endometriosis were significantly higher than those in controls (P<0.01). The sensitivity and speciality of CA125 for endometriosis was 70.2% and 80.4% respectively, the sensitivity and speciality of CA199 for endometriosis was 62.4% and 71.8% respectively, and speciality of SIL-2R was 89.5% and 60.2% respectivity the sensitivity of the combined determination of CA125, CA199 and SIL-2R for endometriosis was 86.8% being significantly higher than that of CA125 and CA199 respectively. Conclusion Combined determination of the serum CA125, CA199 and SIL-2R levels in serum can increase the diagnostic sensitivity for endometriosis.