PTEN和HER-2／neu在上皮性卵巢癌组织中的表达及相关性

目的探讨卵巢癌组织中PTEN和HER-2／neu的表达与肿瘤行为的关系及意义。方法采用免疫组织化学S-P法检测了158例卵巢癌，20例卵巢良性肿瘤和20例正常卵巢组织中PTEN蛋白和HER-2／neu的表达。结果卵巢癌组织PTEN阳性率（34．18％）明显低于正常卵巢组织（90．00％）和卵巢良性肿瘤组织（80．00％）。卵巢癌组织HER-2／neu过表达率显著高于卵巢正常组织和卵巢良性肿瘤（P〈0．01）。卵巢癌组织中PTEN阳性表达强度与HER-2／neu过表达强度存在显著的负相关。PTEN、HER-2／neu阳性率与卵巢癌的组织分化程度、病理分期有关。结论PTEN蛋白表达的缺失和HER-2／neu过表达可能导致细胞增殖失控，与卵巢癌的发生、发展有关。

The expression and relationship of PTEN and HER-2/neu in the tissue of ovarian cancer

Objective To investigate the expression of PTEN and HER-2/neu protein in ovarian carcinoma and their relationship. Methods The expression of PTEN and HER-2neu protein in 158 cases of epithelial ovarian carcinoma,20 cases of benign ovarian cystoadenoma and 20 cases of normal ovarian tissue were detected by S-P immunohistochemical method. Results In the normal ovarian and benign ovarian tumor tissue,the positive rate of PTEN protein（90% ,80% ） were higher than those in ovarian cancer tissue （34.18%）. The over expression of Her-2/neu in epithelial ovarian carcinoma was higher than that in benign ovarian tumors. （P 〈 0.01）. The positive rates of PTEN and HER-2/neu were closely correlated with levels of histological differentiation and clinical pathology stages. Conclusions The PTEN protein expression flaw and over expression of HER-2/neu may result in the cell proliferation out of regulation, and related with occurrence and development of ovarian cancer.