Membrane–cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation |
| |
Authors: | Vincent Das,Bé atrice Nal,Anne Roumier,Vannary Meas-Yedid,Christophe Zimmer,Jean-Christophe Olivo-Marin,Pascal Roux,Pierre Ferrier,Alice Dautry-Varsat, André s Alcover |
| |
Affiliation: | 1Unitéde Biologie des Interactions Cellulaires, CNRS URA 1960; 2Unitéd'Analyse d'Images Quantitative, CNRS URA 1947; 3Centre d'Imagerie Dynamique, Institut Pasteur, Paris, France; 4Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Universitéde la Méditerranée, Marseilles France |
| |
Abstract: | Summary: Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T‐cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we discuss the involvement of the membrane‐microfilament linker ezrin. We propose that ezrin is a component of the cytoskeleton‐mediated architecture of the immunological synapse that plays a role in T‐cell receptor clustering, protein kinase C θ translocation and intracellular signaling. |
| |
Keywords: | |
|
|