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Epidemiology of vertically transmitted HIV-1 infection in Switzerland: Results of a nationwide prospective study |
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| Authors: | C. Kind B. Brändle C. -A. Wyler A. Calame C. Rudin U. B. Schaad J. Schüpbach H. -P. Senn L. Perrin L. Matter |
| Affiliation: | (1) Division of Neonatology, Kantonsspital, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland;(2) Department of Paediatrics, University of Zürich, Switzerland;(3) Department of Paediatrics, University of Genève, Switzerland;(4) Department of Paediatrics, University of Lausanne, Switzerland;(5) Department of Paediatrics, University of Basel, Switzerland;(6) Department of Paediatrics, University of Bern, Switzerland;(7) Swiss National Centre for Retroviruses, Zürich, Switzerland;(8) Institute for Medical Microbiology, University of Basel, Switzerland;(9) Laboratory for Viral Serology, University of Genève, Switzerland;(10) Institute for Clinical Microbiology and Immunology, St. Gallen, Switzerland;(11) Institute for Medical Microbiology, University of Bern, Switzerland |
| Abstract: | A nationwide study involving 286 children of human immunodeficiency virus (HIV)-infected mothers living in Switzerland has been performed with the participation of all paediatricians interested in HIV infection in the country. Of these children 201 could be followed up prospectively from birth up to a median age of 22 months. Prevalence of HIV infection in Swiss parturients was estimated at 0.1% and apparently remained stable from 1986 to 1989. Vertical transmission rate was estimated at 14%–20%. Variables of maternal or perinatal history were not associated with transmission rate. Transmission to pairs of siblings of the same mothers was discordant in 33% (6 of 18), with always the elder sibling being infected. Postneonatal mortality in infants of HIV-infected mothers followed up from birth was increased 15-fold over the general population with a very high incidence (2 in 100) of sudden infant death apparently unrelated to HIV infection.A complete list of all the participants in the study is available on request |
| Keywords: | HIV infections HIV seroprevalence Child Transmission Epidemiology |
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