| Abstract: | PURPOSE: The aim of the work was to define the relationships between the endothelin-1 level in blood serum of glaucoma patients concerning the visual field defects and the number of nerve fibers. MATERIAL AND METHODS: 24 women and 14 men, aged 38-74 year (mean 53.4 year) with primary open angle glaucoma, without any systemic diseases. The control group consisted of 20 healthy women and men, aged 34-70 year (mean 52.6 year). The endothelin-1 level was tested with the enzymo-immunologic method from the blood serum. The visual field defects were examined with the Humphrey static perimetry. The nerve fibers were analyzed with the Gdx apparatus. RESULTS: Mean value of ET-1 in blood serum were similar in both examined groups, it was 0.51 in group of glaucoma patients and 0.54(fmol/l) in the control group. There were no significant correlations between ET-1 level, static perimetry, GDx parameters and age in the group of patients with POAG. The statistics significances were stated for ET-1 level and MD-parameter in static perimetry (p < 0.03) and ET-1 level with The Number--the GDx parameter (p < 0.03). CONCLUSION: There was no significant level of ET-1 in blood serum in group of patients with POAG. There have not been stated any relationships between the static perimetry and GDx changes in patients with POAG to endothelin-1 level in blood serum. It is the preliminary communication. |
