肺结核患者CD4、CD8淋巴细胞变化分析

目的　观察肺结核患者CD4、CD8淋巴细胞变化,探讨其免疫状态的改变及其意义。方法 用流式细胞仪测定31例成人肺结核及12例对照组的CD4、CD8计数值,对测定结果进行统计学分析。结果 病人组CD4值明显下降,CD8值无明显变化,CD4下降幅度与病情严重程度、排菌状态无明显关联。结论 成人肺结核患者存在以CD4T淋巴细胞下降为突出表现的细胞免疫受损,但其对病情发生、发展无独立的影响作用。

Analysis on the change of CD4 and CD8 lymphocytes in pulmonary tuberculosis patients

Objective To observe the change of CD4 and CD8 lymphocytes in pulmonary tuberculosis patients and to explore the trend and significance of their immune function Methods Determine the CD4 and CD8 values in 31 adult pulmonary tuberculosis patients and 12 control cases with flow cytometry. And then make a statistical analysis based on the determining results .Results The CD4 values of the patients declined obviously, the CD8 values had no obvious difference . There was no obvious relationship between the decline extent of CD4 values and the patients' illness condition, the condition of the discharge of bacteria. Conclusion Damage of cellular immune function existed in the adult pulmonary tuberculosis patients, which prominently manifested in the form of the decline of the CD4T lymphocytes , but it had no absolute effective impact on the occurrence and development of illness .