| 新辅助化疗对乳腺癌细胞凋亡和增殖的影响 |
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| 引用本文： | 孟凡青,张琼,吕翔,周祀乔.新辅助化疗对乳腺癌细胞凋亡和增殖的影响[J].临床肿瘤学杂志,2005,10(5):515-517. |
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| 作者姓名： | 孟凡青 张琼 吕翔 周祀乔 |
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| 作者单位： | [1]南京大学附属鼓楼医院病理科,南京210008 [2]南京大学医学院,210008 |
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| 基金项目： | 南京市科委资助项目（项目号：99716） |
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| 摘 要： | 目的：观察乳腺癌新辅助化疗后癌细胞凋亡及增殖程度的变化,判断化疗疗效.方法：新辅助化疗手术标本44例和术前未接受化疗的对照组37例,进行Ki67及PCNA免疫组织化学染色和TUNEL原位细胞凋亡检测,并进行统计学处理.结果：化疗组Ki67、PCNA和AI的阳性细胞数比率分别为11.8%、31.3%和69.8%,对照组分别为21.6%、62.8%和52.8%,化疗组和对照组相比均有显著性差异.结论：新辅助化疗能抑制乳腺癌细胞的增殖,诱导凋亡.
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| 关 键 词： | 乳腺癌 新辅助化疗 细胞凋亡 增殖 |
| 文章编号： | 1009-0460(2005)05-0515-03 |
| 收稿时间： | 01 26 2005 12:00AM |
| 修稿时间： | 03 22 2005 12:00AM |
Effects of neoadjuvant chemotherapy on apoptosis and proliferation of breast cancer |
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| MENG Fan-qing, ZHANG Qiong, LV Xiang,ZHOU Si-qiao..Effects of neoadjuvant chemotherapy on apoptosis and proliferation of breast cancer[J].Chinese Clinical Oncology,2005,10(5):515-517. |
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| Authors: | MENG Fan-qing ZHANG Qiong LV Xiang ZHOU Si-qiao |
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| Institution: | Department of Pathology, The Affiliated Drum Tower Hospital, Nanjing University Medical College, Nanjing 210008, China |
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| Abstract: | Objective:To observe the change of the apoptosis level and proliferate degree of breast carcinomas after preoperative chemotherapy.Methods:Immunohistochemical labeling performed with the Ki67 and PCNA monoclonal antibodies, and TUNEL (terminal-deoxynucleotidyl transferase mediated d-UTP nick end labeling) were used.Results:The expressions of Ki67, PCNA in preoperative groups (11.8%, 31.3%) were significantly lower than those in control groups (21.6%, 62.8%). Apoptosis index of preoperative group (69.8%) was higher than that in control group (52.8%).Conclusion:The study showed neoadjuvant chemotherapy inhibited the proliferatation of breast cancer cell and induced apoptosis. |
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| Keywords: | Breast cancer Neoadjuvant chemotherapy Apoptosis Proliferation |
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