多学科协作诊治模式下治疗不可切除结直肠癌67例

目的:总结多学科协作诊治模式下治疗不可切除结直肠癌的经验.方法:本研究纳入67例符合条件的患者,其中男38例,女29例,平均年龄为55.62岁,右半结肠癌15例,左半结肠癌9例,直肠癌43例.67例患者均经综合治疗小组评估为不可切除,且组织学证实为结直肠癌.患者的治疗由结直肠专科医师与多学科组成的综合治疗小组完成.结果:67例患者中,无完全缓解(CR)病例,部分缓解(PR)43例,稳定(ND)16例,进展(PD)8例;近期症状缓解率100%;生存期10-38mo,平均24mo;9例患者实施了根治性手术,外科干预比例为13.4%(9/67);总并发症发生率为52.2%(35/67).结论:采用综合治疗方式,包括全身化疗、介入化疗、局部放疗、分子靶向治疗、中医中药治疗、手术治疗以及针对病灶的局部治疗,可提高不可切除结直肠癌患者的生存质量,延长存活时间.

Management of unresectable colorectal cancer by multimodality therapy:An analysis of 67 cases

AIM:To summary our experience with multimo-dality therapy of unresectable colorectal cancer.METHODS:A total of 67 patients were included in this study,including 15 patients with rightsided colon cancer,9 with left-sided colon cancer,and 43 with rectal cancer.All cases were assessed as unresectable by the multidisciplinary team and histologically confirmed as colorectal cancer.Multimodality therapy was performed by colorectal specialists and the multidisciplinary team.RESULTS:Of all 67 patients,no patients achieved complete remission,43 achieved partial remission,16 had stable disease,and 8 had progressive disease.The short-term remission rate was 100%.The survival duration ranged from 10 to 38 months,with an average of 24 months.Nine(13.4%) patients underwent radical surgery.The total complication rate was 52.2%(35/67).CONCLUSION:Multimodality therapy allows improving quality of life and prolonging survival time in patients with unresectable colorectal cancer.