Differential effects of procarbazine and methylnitrosourea on the accumulation of O6-methylguanine and the depletion and recovery of O6-alkylguanine-DNA alkyltransferase in rat tissues |
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| Authors: | Valavanis, Christos Souliotis, Vassilis L. Kyrtopoulos, Soterios A. |
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| Affiliation: | Laboratory of Chemical Carcinogenesis, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation Vassileos Constantinou Avenue 48, Athens 11635, Greece |
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| Abstract: | The kinetics of accumulation of the premutagenic DNA adductO6-methylguanine (O6-meG) in the liver, blood leukocytes, lymphnodes and bone marrow of rats was examined and compared aftersingle or multiple doses of procarbazine, a methylating cytostaticdrug employed in the treatment of Hodgkin's lymphoma patients,and methylnitrosourea (MNU), an experimental methylating agentand carcinogen. Maximal O6-meG levels occurred 12 h afteradministration of single doses of procarbazine (10 mg/kg) orMNU (1 mg/kg), thereafter decreasing with halflives of |
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