氟比洛芬酯超前镇痛在妇科腹腔镜手术中的应用

目的：探讨预注射氟比洛芬酯用于妇科腹腔镜手术超前镇痛的作用。方法：ASAⅠ—Ⅱ级择期妇科腹腔镜手术60例，随机分为治疗组和对照组各30例．对照组缝皮前不用任何镇痛药，治疗组缝皮前10—15min静脉注射氟比洛芬酯50mg。分别于术后1h（T1），4h（T2），8h（T3）对切口疼痛采用BCs评分标准．分为5分，当评分0分时给予哌替啶100mg肌肉内注射镇痛，记录两组术后使用哌替啶的时闻．例数及次数．咽喉疼痛发生率等不良反应。结果：治疗组术后1、4、8小时疼痛评分均低于对照组（P〈0．01），术后使用哌替啶的时间，例数及次数均低于对照组（P〈0．01），治疗组和对照组咽喉疼痛发生率分别为15％和360％（P〉005），两组的不良反应除恶心呕吐外差异无显著性（P〉0．05）。结论：氟比洛芬酯超前镇痛用于妇科腹腔镜手术，能有效缓解术后切口疼痛，减轻炎症反应．减少术后镇痛药的使用和不良反应，且术后苏醒迅速安全。

Flurbiprofen Ester Preemptive Analgesia in Gynecologic Laparoscopic Surgery

Objective： To study the preemptive analgesia of flurbiprofen ester in gynecological laparoscopic surgery. Methods： 60 patients （ASAI-II） under elective gynecologic laparoscopic surgery were randomly divided into treatment group and control group （n=30）. Control group without any pre-analgesic treatment; Treatment group： intravenous injection of flurbiprofen ester 50mg 10-15min before sewing leather. Score the pain level after lh （T1）, 4 h（T2）, 8 h（T3） using the standard BCS, once patients at 0 score, intramuscular injection 100mg pethidine, recorded the time and frequency of each group, as well as the incidences of throat pain and other adverse reactions. results： Pain scores of treatment group at 1,4,8 hours were lower than the control group（P〈0.01）. The number and frequency of pethidine injection were lower in treatment group than control group（P〈0.01 ）. The incidence of sore throat were 15%（ treatment group） and 60% （control group） （P〉0.05）. There were no significant difference of other adverse events between two groups except nausea and vomiting （P〉0.05）. Conclusion： Flurbiprofen ester pre-emptive treatment in gynecologic laparoscopic surgery can effectively relieve postoperative incisional pain, reducing inflammation reaction