喹硫平和利培酮治疗精神分裂症的对照研究

目的以利培酮为对照,探讨喹硫平治疗精神分裂症的疗效和副作用。方法将60例符合CCMD-3诊断标准的精神分裂症病人随机分为两组,分别给予喹硫平和利培酮治疗8周。于治疗前和治疗后1、2、4、8周末采用阳性症状和阴性症状量表(PANSS)评定临床疗效,副反应量表(TESS)评定副反应。结果治疗8周后,两组疗效近似(P>0.05),喹硫平组和利培酮组的显效率差异无显著性(P>0.05);喹硫平组的副反应发生率低于利培酮组,但差异无显著性(P>0.05)。利培酮组锥体外系副反应和内分泌改变的发生均明显高于喹硫平组(P<0.05)。结论喹硫平对精神分裂症患者的疗效与利培酮相当,副作用较小。

A comparative study between seroquel and risperidone in the treatment of schizophrenia

Objective To investigate the clinical efficacy and side effects of seroquel in the treatment of schizophrenia.Methods A total of 60 patients met the criteria of CCMD-3 for schizophrenia were randomly assigned to two group treated with seroquel or risperidone for 8 weeks.The Positive and Negative Symptoms Scale (PANSS) and Treatment Emergent Symptoms Scale(TESS) were used to evaluate efficacy and adverse effects before treatment and at the end of 1st,2nd,4th and 8th week.Results The therapeutic efficacy in seroquel group was similar to that in risperidone group(P>0.05),and there was no significant difference between the two groups(P>0.05).Incidence of adverse effects in seroquel group was lower than that in risperidone group,but the difference was not significant(P>0.05),The incidences of extra-pyramidal symptoms and endocrine change in risperidone group were significantly higher than those in seroquel group.Conclusion Seroquel is as effective as risperidone for treating schizophrenia with lower side effects.