曲唑酮治疗苯二氮(艹卓)类依赖患者疗效观察

目的观察对抗焦虑药苯二氮类(BDZ)依赖的患者使用曲唑酮替代的疗效。方法符合DSM-Ⅲ-R诊断标准的15例BDZ依赖患者住院治疗2周,给予曲唑酮(50~150mg,1次/d),并快速减少其BDZ类药物的每日用量。之后每周进行一次门诊检查,随访3个月,剂量根据个人情况增减。结果在BDZ药物逐渐减量阶段很少出现戒断现象,在随访的3个月中,所有患者保持停用BDZ类药物且没有滥用曲唑酮现象,同时焦虑、抑郁症状明显改善。汉密尔顿焦虑量表(HAMA)评分从12.5降为5.3(P<0.05),汉密尔顿抑郁量表(HAMD)评分从11.8降为4.9(P<0.05)。结论曲唑酮对BDZ类药物有滥用危险的焦虑患者可作为长期治疗的重要替代药,且曲唑酮没有潜在的滥用可能性。

Clinical Observation of Trazodone in Treatment of Anxiety with Addiction to Benzodiazepines

Objective To evaluate the therapeutic effect of trazodone in the treatment of anxiety with addiction to benzodiazepines(BDZ).Methods 15 patients meeting DSM-III-R diagnostic criteria with BDZ addiction were assigned to trazodone(50~150mg qd) of 2 weeks,with rapid reducement of the daily dose of BDZ.Followed by weekly outpatient examination and dosage adjustment in accordance with each patient's condition for next 3 months.Results There were few withdrawal reaction during the phase of gradually reducement of BDZ.None of the patients used BDZ or abused trazodone during the follow-up periods of 3 months,and the symptoms of anxiety and depressant advanced.HAMA Score was reduced from 12.5 to 5.3(P<0.05),and HAMD Score from 11.8 to 4.9(P<0.05).Conclusion Trazodone can be an important drug in the treatment of anxiety with addiction to BDZ for long-term treatment without potential possibility of abusement.