+Gz暴露对大鼠记忆功能和行为的影响

目的 探讨不同水平 Gz暴露对大鼠记忆功能和行为的影响。方法 24只雄性SD大鼠随机分为对照组、 6Gz组和 10Gz组3组，每组8只。 Gz暴露大鼠分别进行 6Gz／3min和 10Gz／3min暴露，记录 Gz暴露后不同时间大鼠记忆功能和行为的变化。结果 与对照组比较， 10Gz组大鼠反应时在 Gz暴露后即刻和2d时显著延长(P＜0．01)，错误次数及错误时间在 Gz暴露后6h时显著增加(P＜0．01)，中央格内停留时间在 Gz暴露后即刻、6h和ld时显著延长(P＜0．01)，站立次数和跨格次数则在 Gz暴露后即刻和2d时显著减少(P＜0．01)；而 6Gz组大鼠仅站立次数在 Gz暴露后即刻和2d时较对照组显著减少(P＜0．01)，其余指标均无显著性差异。结论 10Gz／3min暴露可引起暂时性大鼠记忆功能降低和行为改变。

Effect of +Gz exposure on memory and behavior in rats

Objective To explore the effect of +G z exposure of different magnitudes on memory and behavior in rats. Methods Twenty four male SD rats were randomly divided into three groups: control group,+6 G z and +10 G z groups. The rats of +G z groups were exposed to +6 G z and +10 G z for 3 min respectively. The memory and behavior in rats were measured before and after +G z exposures. Results As compared with that of control, reaction time prolonged significantly immediately and 1 day after +10 G z exposure ( P< 0.01); number of errors and time of errors increased significantly 6 hours after +10 G z exposure ( P< 0.01); time of stay in center grille prolonged significantly immediately, 6 hours and 2 days after +10 G z exposure ( P< 0.01); number of rearing and number of crossing decreased significantly immediately and 2 days after +10 G z exposure ( P< 0.01 ); number of rearing decreased significantly immediately and 2 days after +6 G z exposure ( P< 0.01 ). Conclusions It is suggested that +10 G z/3 min exposure may induce temporary disturbance of memory function and changes of behavior in rats.