稳定性冠状动脉心脏病患者心绞痛程度与其认知功能的相关性研究

目的分析稳定性冠状动脉心脏病(stable coronary artery disease,SCAD)患者心绞痛(angina pectoris,AP)程度与其认知功能的相关性,探索不同AP程度的SCAD患者认知功能下降领域。方法 2015年11月至2016年6月采用方便抽样法选取上海市某三级甲等医院心内科SCAD住院患者177例为研究对象,使用蒙特利尔认知评估量表(北京版)进行横断面调查。结果运用多元线性回归分析,校正年龄、性别、文化程度、体质指数、是否独居、心肌梗死史、高血压、糖尿病患病情况后,SCAD患者AP程度与总体认知功能及除定向力外的6个认知领域均存在相关性(均P0.05)。多因素调整后,与无AP者相比,轻度AP者与重度AP者认知功能总分分别降低1.3分(P=0.017)和3.3分(P0.001);与无AP者相比,轻度AP者在注意力、语言、抽象思维、定向力等4个认知领域得分降低,重度AP者7个认知功能领域得分均降低,差异均有统计学意义(均P0.05)。结论 AP程度是SCAD患者认知功能下降的独立危险因素,不同AP程度的患者认知功能下降领域不同。

Study on the Correlation between the Angina Pectoris Severity and the Cognitive Function in Pa-tients with Stable Coronary Artery Disease

Objective To examine the association between angina pectoris (AP)severity and cognitive function among stable coronary artery disease(SCAD)patients,in order to explore the specific fields of cognitive decline among SCAD patients with different AP severity.Methods By convenience sampling,177 cases were selected and investigated by using Montreal cognitive assessment(MoCA)Peking version.Re-sults After adj usting for age,gender,education level,body mass index,solitary,myocardial infarction his-tory by multiple linear regression,the prevalence of hypertension and diabetes,the AP severity among SCAD patients was associated with their cognitive function and 6 fields of MoCA except directional force (P<0.05).Compared with SCAD patients with no AP ,the average score of MoCA decreased 1.3 (P=0.017)and 3.3(P<0.001)in patients with mild AP and severe AP respectively.As for the 7 fields of Mo-CA,the average score of attention,language,abstract thinking,and directional force decreased in SCAD pa-tients with mild AP as compared with patients who didn't have AP(P<0.05).Conclusions The AP sever-ity is a risk factor for the cognitive decline among SCAD patients.The fields of cognitive impairment are different in SCAD patients with varying degrees of AP.