肝纤退黄方合654-2注射液治疗肝硬化伴顽固性黄疸临床观察

目的：观察肝纤退黄方合654—2注射液治疗肝硬化伴顽固性黄疸的疗效,并进行理论探讨。方法：选择60例透明质酸(HA)大于400ng／ml以上同时伴有一氧化氮(NO)增高的肝硬化伴黄疸患者,随机分为实验组和对照组观察治疗3个月。实验组用肝纤退黄方合654—2注射液治疗,对照组用常规疗法。结果：实验组可明显使胆红素(TB)多数复常,球蛋白(GLB)、HA、No降至接近正常水平;40％门静脉原宽度缩小,50％维持不变;30％脾厚度缩小,40％不变。1年后随访：实验组22例中20例上述指标保持稳定,2例复发;对照组24例中7例保持稳定,10例发生脾功能亢进,2例发生肝癌,5例再发。结论：肝纤退黄方合654—2注射液治疗肝硬化伴顽固性黄疸具有良好疗效。

Clinical Observation of the Treatment of 654-2 Injection and "GanXian Tui Huang Recipe" on Liver Cirrhosis with Intractable Jaundice

Obiective:To observe the effect of 654-2 injection and " GanXian Tui Huang Recipe" on hepatic fibrosis with intractable jaundice. Methods:60 patients were treated for 3 months and randomly divided into control group and experiment group. The experiment group was treated with 654-2 injection and "Gan Xian Tui Huang Recipe" and the control group was treated with routine treatment. All the patients have high level of Nitrogen monoxide (NO) , hyaluronic acid (HA >400 ng/ml)and hepatic fibrosis with intractable jaundice. Results:In experiment group,the serum total bilirubin(TB) ,globulin(GLB) ,HA and NO were significantly decreased to normal level;40% of portal veins were narrowed,50% of them were not changed;30% of spleen were thinned,40% of them were fixed. 1 year later,20 patients were stable and 2 patients were recurrent in 22 patients of the experiment group;in 24 patients of the control group, 7 patients were stable, 10 patients had hypersplenia, 2 patients occurred hepatocarcinoma and 5 patients were recurrent Conclusion:Effect of 654-2 injection and "Gan Xian Tui Huang Recipe" on hepatic fibrosis with intractable jaundice is significant.