Phenotypic and genotypic characterization of prolyliminopeptidase-negative Neisseria gonorrhoeae isolates in Denmark |
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| Authors: | H Fjeldsøe-Nielsen M Unemo H Fredlund S V Hjorth L M Berthelsen H M Palmer A Friis-Møller |
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| Institution: | (1) Department of Clinical Microbiology, H:S Hvidovre Hospital, Kettegaard allé 30, 2650 Hvidovre, Denmark;(2) Swedish Neisseria gonorrhoeae Reference Laboratory, Department of Clinical Microbiology, Örebro University Hospital, 70185 Örebro, Sweden;(3) Danish Neisseria gonorrhoeae Reference Laboratory, Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark;(4) Scottish Neisseria gonorrhoeae Reference Laboratory, Department of Clinical Microbiology, Royal Infirmary of Edinburgh, Little France, Edinburgh, EH16 4SA, Scotland, UK |
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| Abstract: | In the study presented here 26 recent Danish clinical isolates of prolyliminopeptidase (PIP)-negative Neisseria gonorrhoeae were phenotypically and genotypically characterized to investigate whether one or more PIP-negative strains are circulating in the Danish community. The profiles of these isolates were compared with those of three isolates from a recent outbreak of PIP-negative N. gonorrhoeae infection in the UK. Twenty-five of the Danish isolates and all three UK isolates had similar antibiograms and were designated serovar IB-4. Genotypic characterization by pulsed-field gel electrophoresis, porB1b gene sequencing, and opa-typing revealed that these isolates were indistinguishable or closely related. The results indicate that at least one PIP-negative N. gonorrhoeae strain is currently circulating in the Danish community, and this strain is indistinguishable from the one that caused an outbreak in the UK.An erratum to this article can be found at |
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