Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice |
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| Authors: | Yang K Feng Y Li Y |
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| Affiliation: | Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an 710032, People’s Republic of China |
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| Abstract: | We investigated the action of baclofen, an agonist for GABAB receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Aδ fibers. Baclofen (10 μM) reduced the amplitude of Aδ fiber-evoked glycine receptor-mediated IPSCs to 20.9±3.0% (n=13), and GABAA receptor-mediated IPSCs to 18.6±3.4% (n=12) of the controls, respectively. The results further suggest modulatory role of GABAB receptor in spinal dorsal horn. |
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| Keywords: | Baclofen Substantia gelatinosa Spinal cord Whole-cell voltage-clamp recording Inhibitory postsynaptic current Rat |
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