自发性高血压大鼠血管外周脂肪组织对血管调节功能的影响

目的观察自发性高血压大鼠（SHR）血管外周脂肪组织释放血管舒张因子功能的改变。方法把26周龄SHR和WKY两组大鼠相邻的两段胸主动脉环分为血管外周脂肪亚组和裸血管亚组，予1×10^-6mmol／L苯肾上腺素（PHE）刺激，比较两亚组血管收缩力的差异；用液体转移的方法，观察WKY孵育血管外周脂肪组织的培养液对裸血管张力的影响。结果WKY组血管外脂肪亚组的收缩力低于裸血管亚组的收缩力（P〈0．05），而SHR两血管亚组的收缩力差异无统计学意义（P〉0．05）；把WKY孵育的血管外脂肪的培养液转移到裸血管诱发其快速舒张。结论WKY的血管外周脂肪组织释放一种可转移性血管舒张因子，降低血管对苯肾上腺素的反应性，调节血管功能。而SHR的血管外周脂肪组织这种血管调节作用减弱；血管外周脂肪组织这种功能异常可能是高血压病血管功能畀常的病理基础之一。

The effects of perivascular adipose tissue on vascular regulatory function in spontaneously hypertensive rats

Objective To observe the functional change of perivascular adipose tissue in spontaneously hypertensive rats （SHRs）. Methods Thoracic aorta was divided into two subgroups： vessel without perivascular adipose tissue subgroup and vessel with perivascular adipose tissue subgroup. The contractile force in two subgroups induced by phenylephrine were compared. We compared the differences of contractile force in two subgroups of WKY group and SHR group. By means of transfer, we observed the effect on vessel without perivascular adipose tissue in WKY caused by the bath solution from perivaseular adipose tissue vessel. Results The contractile force of perivascular adipose tissue subgroup in WKY group was lower than that in subgroup without perivascular adipose tissue （ P 〈 0.05 ）. There was no statistical difference of the contractile force between two subgroups in SHR group （P 〉 0.05）. The bath solution transferred from perivaseular adipose tissue subgroup in WKY could led to a quick relaxation of vascular without perivascular adipose tissue. Conclusions The perivaseular adipose tissue in WKY might decrease the responsiveness to phenylephrine of vessel, and it depend on perivascular adipose tissue releasing a transferable vessel relaxation factor. The function aboved of perivascular adipose tissue in SHR was inhibited. The pathological mechanisms of hypertension might involve the dysfunction of perivascular adipose tissue.