糖尿病患者病程及血清胱抑素C水平与糖尿病肾病的关系

目的探讨糖尿病患者在尿白蛋白排泄率正常时病程与血清胱抑素C水平的关系及各不同病程组与糖尿病肾病Ⅲ期组血清胱抑素c水平的关系。方法对160例糖尿病患者进行血清胱抑素C水平测定，将其中120例尿白蛋白排泄率正常糖尿病患者依病程分三组：A组40例，病程〈5年；B组40例，病程5～10年；C组40例，病程〉10年。余40例糖尿病肾病Ⅲ期患者为D组。结果A、B、C三组血清胱抑素c水平依次为（0．73±0．20）、（O．84±0．19）、（0．96±0．18）mg／L，各组间比较差异有统计学意义（P〈0．05），A、B组与D组（0．99±0．21）mg／L相比差异亦有统计学意义，而C组与D组相比血清胱抑素c水平差异无统计学意义（P〉0．05）.结论糖尿病患者肾脏损害程度随糖尿病病程的延长不断加重，病程超过10年时肾脏损害程度已与糖尿病肾病Ⅲ期相当.

Relationship between the course of diabetes mellitus,the serum cystatin C level and diabetic nephropathy

Objective To investigate the serum cystatin C （Cys C） level in patients with diabetes mellitus （DM） , and analyzed the relationship between Cys C and the course of DM with normal urinary albumin excretion rate （UAER）. Then analyzed the relationship of the Cys C level between patients of DM with normal UAER and patients of diabetic nephropathy phase Ⅲ. Methods The serum Cys C levels of 120 DM patients with normal UAER and 40 DM patients of diabetic nephropathy phase Ⅲ were detected. One hurdred and twenty cases of DM patients with normal UAER were divided into group A（the course of DM 〈 5 years, 40 cases）, group B（ the course of DM 5 - 10 years, 40 cases）and group C （the course of DM 〉 10 years, 40 cases）according to their course of DM. Take the 40 cases of diabetic nephropathy phase Ⅲ patients as group D. Results Cys - C levels were highest in group C （0.96 ± 0.18） mg/L,followed by group B （0.84 ±0.19）mg/L, and group A （0.73 ±0.20）mg/L（ P 〈0.05）. Cys-C levels of group D （0.99 ±0.21）mg/L were much higher than that of group A and B （ P 〈 0.05）. But there was no significant difference between group C and D （ P 〉 0.05）. Conclusions When UAER is normal, renal function damage is aggravated gradually with the increasing course of DM; and when the course of DM more than 10 years, the renal function damage degree just as the diabetic nephropathy phase Ⅲ.