血尿酸水平与冠状动脉病变的关系

目的研究冠心病患者血清尿酸水平与其冠脉病变程度的关系。方法选择2009年至2010年在郑州大学第一附属医院住院的冠心病患者192例，按照其冠脉造影结果分为单支病变组（52例）、双支病变组（43例）、三支病变组（55例）及健康对照组（42例），入院时患者均测定尿酸水平。结果①四组患者在尿酸，低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、C-反应蛋白等方面比较差异均有统计学意义（P〈0．05）。②四组患者尿酸水平分别为（330±81）μmmol／L、（341±80）μmmol／L、（372±83）μmmol／L、（288±78）μmmol／L，其水平随着病变血管数的增加而升高，显示其与冠脉病变程度密切相关（r=0．43，P〈0．05）。结论冠心病患者尿酸水平与其冠脉病变程度呈密切相关。

The relationship between serum uric acid level and coronary artery disease

Objective To investigate the correlation between the level of uric acid level and the extent of coronary lesions in patients with coronary heart disease （ CHD）. Methods One hundred and ninety -two patients in our hospital from 2009 to 2010 were divided into four groups： sin- gle - branch （ 52 patients） , double - branch （ 43 patients） , three - branch （ 55 patients） and normal control group （42 patients）. Uric acid were measured in all the patients. Results （1）There were significant differences in uric acid, LDL - C, HDL - C and CPR among the four groups （P 〈 0.05）. （2）The uric acid level in the four groups were （330 ±81 ） μmmol/L, （341±80） μmmol/L, （372 ± 83 ） μmmol/L, （288±78 ） μmmol/L, which increased with the number of stenosed vessels increased. Uric acid level was significantly correlated with the severity of coronary artery lesion （r = 0.38 ,P 〈 0.05 ）. Conclusions Uric acid level in patients with CHD is closely related to the severity of coronary lesion.