白细胞介素-6和超敏C-反应蛋白与原发性高血压病分级、危险度分层关系

目的探讨白细胞介素-6（IL-6）和超敏c-反应蛋白（hs—CRP）的血浆水平与原发性高血压病分级、危险度分层关系。方法原发性高血压病患者80例，按临床诊断分级分为：1级20例，2级30例，3级30例；危险度分层分为：低危组13例，中危组16例，高危组15例，极高危组36例。另选择健康对照组20例。测定IL-6、hs—CRP的水平，比较各组间的差异。结果原发性高血压病组IL-6和hs—CRP显著高于正常对照组（P〈0．05），且随着原发性高血压病患者血压分级水平及危险度分层递增而增加，差异有统计学意义（P〈0．05）；IL-6和hs—CRP水平变化呈正相关（r=0．46．P〈0．05）。结论IL-6和hs—CRP浓度能反应原发性高血压病患者血压水平及危重程度，可能参与原发性高血压病的发生、发展及转归，可考虑作为原发性高血压病危险度的新临床量化指标。

Relations of plasma interleukin -6, hypersensitive C -reactive protein with the stage and risk stratification in essential hypertension

Objective To study the relationship between interleukin - 6 （ IL - 6） , hypersensitive C -reactive protein（ hs- CRP） with the stage and risk stratification in essential hypertension （ EH ）. Methods Eighty EH patients, graded by clinical diagnosis （ stage 1 ： 20 cases, stage 2 ： 30 ca- ses, stage 3：30 cases） , risk stratification （low- risk group of 13 patients, intermediate -risk group of 13 cases, high- risk group of 15 cases, very high- risk group of 36 cases） ,and control group consisted of 20 healthy people . The level of IL - 6 and hs - CRP was measured. Person correlation analysis was used to analyze the relationship between the level of IL - 6 and hs - CRP. Results The levels of L - 6 and hs - CRP were significantly higher in EH groups than those in control group （ P 〈 0.05 ）. And blood pressure in hypertensive patients increases with graded levels and risk stratification increases, the difference was significant （ P 〈 0.05 ） , IL - 6 and hs - CRP levels were positively correlated （ r = 0.46, P 〈 0.05 ）. Conclusions IL - 6 and hs - CRP levels can reflect the level of blood pressure in essential hypertension, may be involved in the occurrence, development and outcome of hypertension, it can be considered as a new clinical hypertension risk quantitative indicators.