临床研究低钾性周期性瘫痪52例临床分析

目的 探讨低钾性周期性瘫痪的临床特征.方法 回顾性分析2008年10月-2010年10月我院收治的52例低钾性周期性瘫痪的临床资料.结果 52例低钾性周期性瘫痪中原发性低钾性周期性瘫痪37例,继发性低钾性周期性瘫痪15例,继发于甲状腺功能亢进症12例、远端肾小管性酸中毒2例、原发性醛固酮增多症1例.主要临床表现为对称性肢体瘫痪,近端重于远端,从下肢发展到上肢.血清钾均降低,肌酸磷酸激酶(CK)增高12例.出现典型低钾性心电图改变30例.口服及静脉补钾为主要治疗措施.转归:痊愈51例,出现室颤死亡1例.结论 低钾性周期性瘫痪病因复杂多样,认识原发性及继发性低钾性周期性瘫痪的临床特征,对诊断、治疗意义重大.

Clinical Analysis of 52 Patients with Hypokalemic Periodic Paralysis

Objective To explore the clinical characteristics of hypokalemic periodic paralysis （HOPP）. Methods Clinical data of 52 patients with HOPP during October 2008 and October 2010 in our hospital were retrospectively analyzed. Results Among 52 patients with HOPP, there were 37 patients with primary hypokalemic periodic paralysis and 15 patients with secondary HOPP including 12 patients with hyperthyroidism, 2 patients with distal renal tubular acidosis and 1 patient with primary aldosteronism. The main clinical features of HOPP were the symmetrical limbs paralysis ; proximalend was severer than that of distal end and lower limbs was earlier than that of upper limbs. All patients＇ serum potassium level decreased, 12 patients＇ creatine kinase （CK） increased. 30 patients＇ typical hypokalemic ECG changed. Oral and intravenous supplementation of potassium was the main treatment. Outcome： 51 patients were cured and 1 case died of ventricular fibrillation. Conclusion The causes of HOPP are complex and diverse, and it is very important to learn the clinical characteristics of primary and secondary periodic paralysis for diagnosis and treatment of HOPP.