Serial assessment of left ventricular morphology and function in a rodent model of ischemic cardiomyopathy |
| |
| Authors: | Vesselina Ferferieva Nicholas D’Elia Brecht Heyde Petr Otahal Frank Rademakers Jan D’hooge |
| |
| Affiliation: | 1.Department of Cardiovascular Sciences, KU Leuven,Leuven,Belgium;2.Menzies Institute for Medical Research, University of Tasmania,Hobart,Australia;3.Baker Heart and Diabetes Institute,Melbourne,Australia |
| |
| Abstract: | Left ventricular remodelling (LVr) occurs post myocardial infarction (MI), predisposing people to heart failure (HF). LV mechanics and morphology are important in this process. We hence sort to characterize LV mechanics and geometry in a post-MI rodent model. Thirty-two male Sprague–Dawley rats (150–200 g) sustained MI (n?=?24) or sham (Sham; n?=?8) surgery. In another six sham rats invasive blood pressure measurements were performed. Ultrasound imaging was done at baseline, and 1, 3, 7, 14, 30 and 60 days following surgery, and LV mechanics and morphology assessed. LV volumes increased with time (p?
|
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
