| 经皮吸收促进剂的研究与应用进展 |
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| 引用本文： | 王文刚,恽榴红,王睿,周筱青. 经皮吸收促进剂的研究与应用进展[J]. 中国新药杂志, 2006, 15(4): 254-261 |
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| 作者姓名： | 王文刚 恽榴红 王睿 周筱青 |
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| 作者单位： | 1. 军事医学科学院毒物药物研究所,北京,100850
2. 解放军总医院临床药理研究室,北京,100853 |
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| 摘 要： | 透皮给药系统作为最成功的非口服控释给药系统之一，可有效避免肝脏首过效应和胃肠道药物降解、调控释药速率及血药浓度、降低服药频率和不良反应、提高患者顺应性。经皮吸收促进剂在透皮给药系统研究中起着重要作用。现就其应用与联用、选择与评价、促透机制研究及其对水溶性和大分子药物的促透作用等方面，对近年来的研究进展进行综述。
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| 关 键 词： | 透皮给药系统 经皮吸收促进剂 促透剂协同联用 |
| 文章编号： | 1003-3734（2006）04-0254-08 |
| 收稿时间： | 2005-08-02 |
| 修稿时间： | 2005-08-02 |
Research and application of penetration enhancers |
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| WANG Wen-gang,YUN Liu-hong,WANG Rui,ZHOU Xiao-qing. Research and application of penetration enhancers[J]. Chinese Journal of New Drugs, 2006, 15(4): 254-261 |
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| Authors: | WANG Wen-gang YUN Liu-hong WANG Rui ZHOU Xiao-qing |
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| Affiliation: | 1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China; 2 Department of Clinical Pharmacology of PLA General Hospital, Beijing 100853 ,China |
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| Abstract: | Transdermal drug delivery system(TDDS)has emerged as one of the most successful non-oral controlled release systems.Major advantages of TDDS include avoidance of drug degradation in hepatic and gastrointestinal,predetermined release rate and blood drug level,less frequent dosage regimen and side effects,and increased patient compliance.Penetration enhancers(PE)play an important role in the TDDS.This review presented the applications and mechanism of PE regarding to delivering macromole- cules and hydrophilic drugs across the skin.Optimization and evaluation of single and combined PE were also discussed. |
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| Keywords: | transdermal drug delivery system(TDDS) penetration enhancers(PE) synergistic combinations of penetration enhancers(SCOPE) |
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