口服青霉素脱敏疗法治疗青霉素皮试阳性梅毒4例

目的 探讨青霉素脱敏疗法在治疗青霉素皮试阳性梅毒中的有效性和安全性。方法 对4例青霉素皮试阳性梅毒患者，采用依次递增青霉素浓度的口服脱敏疗法，成功之后行青霉素G和苄星青霉素联合治疗。结果 4例青霉素皮试阳性梅毒患者均未发生不良反应，脱敏结束时再行青霉素皮试，4例中3例转为阴性。4例患者均成功完成青霉素驱梅治疗。结论 青霉素脱敏治疗对青霉素皮试阳性梅毒患者可短暂脱敏，且口服脱敏疗法安全可靠。

Desensitization Therapy with Penicillin Per Os in the Treatment of 4 Syphilis Patients with Skin Tests Positive for Penicillin

Objective To probe into the reliability and security nf desensitization therapy with penicillin per us in the treatment of syphilis patients with skin test positive for penicillin. Methods Desensitization therapy with penicillin per us administered in progressively increasing concentrations was adopted in 4 syphilis patients with skin tests positive for penicillin. The patients were then treated with penicillin G in combination with benzathine penicillin G if the desensitization was successful. Results No adverse reactions were encountered in the course of treatment of the 4 cases of syphilis showing skin tests positive fnr penicillin. Skin test reactions in 3 of the 4 patients turned to be negative for penicillin at the termination of the desensitization therapy. All the 4 patients completed their antisyphilitic treatment successfully. Conclusion Desensitization therapy with penicillin was shown to result in a transient desensitization in syphilis patients with skin tests positive for penicillin, and the desensitization therapy with penicillin per us prnved to he reliahle and secure.