| 榄香烯处理瘤苗抗原致敏的树突状细胞的抗肿瘤效应研究 |
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| 引用本文： | 薛冰,施广霞,朴花,金梅,钱振超. 榄香烯处理瘤苗抗原致敏的树突状细胞的抗肿瘤效应研究[J]. 现代免疫学, 2000, 20(5): 292-294 |
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| 作者姓名： | 薛冰 施广霞 朴花 金梅 钱振超 |
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| 作者单位： | 大连医科大学肿瘤生物治疗研究所,大连,116027 |
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| 基金项目： | 国家自然科学基金重点资助项目(No．39730440-II)和辽宁省科委博士科研启动基金资助(No．941065) |
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| 摘 要： | 本文采用 β 榄香烯处理小鼠H2 2肝癌亚系HCa F ,提取榄香烯瘤苗可溶性上清作为粗制肿瘤抗原 ,制备抗原冲击(pulsed)的树突状细胞 ,研究其抗瘤作用及机制。结果表明榄香烯瘤苗抗原冲击的树突状细胞可诱导对HCa F瘤株的MHC非限制性免疫应答 ,继承性转输后对HCa F瘤株攻击有免疫保护效应 ;体外可激发脾不粘附细胞活化增殖和加强杀瘤细胞活性。
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| 关 键 词： | 树突状细胞 榄香烯瘤苗 抗原递呈 |
| 文章编号： | 1001-2478(2000)05-0292-03 |
| 修稿时间： | 1999-10-13 |
Immunoprophylactic Effects and Mechanism of Action of Dendritic Cells Pulsed with Soluble Supernatant of Elemene-TCV Against Hca-F |
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| Xue Bing,Shi Guangxia,Piao Hua,Jin Mei,Qian Zhenchao. Immunoprophylactic Effects and Mechanism of Action of Dendritic Cells Pulsed with Soluble Supernatant of Elemene-TCV Against Hca-F[J]. Current Immunology, 2000, 20(5): 292-294 |
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| Authors: | Xue Bing Shi Guangxia Piao Hua Jin Mei Qian Zhenchao |
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| Affiliation: | Xue Bing,Shi Guangxia,Piao Hua,Jin Mei,Qian Zhenchao;(Institute of Oncology, Dalian Medical University, Dalian 116027) |
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| Abstract: | The immunoprophylactic effects and mechanism of action of dendritic cells(DC) pulsed with soluble supernatant extracted from elemene-TCV of HCa-F to prepare tumor antigen-pulsed DC were investigate in this study It was found that DC pulsed with supernatant of elemene-TCV could induce anti-tumor immune responses of MHC non-restricted fashion against HCa-F When adoptively transferred,they could induce also active immunoprophylactic effect against the challenge with HCa-F and could prime the non-adherent spleenic cells to proliferate in vitro,as well as could enhance the non-MHC restricted cytotoxicity against HCa-F |
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| Keywords: | dendritic cell elemene-tumor cell vaccine antigen presentation |
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