抗反转录病毒治疗HIV/AIDS初治患者232例结果分析

目的观察艾滋病（HIV/AIDS）初治患者接受国产药为主的高效抗反转录病毒治疗（HAART）的疗效,为规范抗病毒治疗提供依据.方法对232例初治HIV/AIDS患者提供国产药为主的HAART并进行定期随访,分析随访3年来的临床疗效、毒副反应及耐药情况.结果 232例患者接受HAART后24、36个月HIV-1病毒载量小于50拷贝/mL的百分比分别为94.8%、85.3%.CD4＋T淋巴细胞计数基线均值（160.1±80）个/mL,接受HAART治疗后,患者CD4＋T淋巴细胞计数逐渐增高,对0、3、6、9、12、18、24、30、36个月来所检测到的CD4＋T淋巴计数进行检验P〈0.01.常见的毒副反应是肝功能损害、外周神经炎、外周脂肪分布异常、骨髓造血功能抑制、皮疹.9例患者治疗过程中出现临床耐药.结论 HIV/AIDS初治患者经国产药为主的抗病毒治疗后虽然毒副反应较大,但病毒学及免疫学应答效果好,临床耐药低.

Clinical Results of 232 Treatment-naive HIV/AIDS Patients after HAART

Objective To observe the therapeutic effect of domestic HAART drug on treatment-naive HIV/AIDS patients,and provide basis for standard antiviral therapy.Methods 232 treatment-naive HIV/AIDS patients were treated with domestic HAART drug and followed up for three years,and clinical therapeutic effect,adverse reaction and drug resistance were analysed.Results The percentage of HIV-1 RNA less than 50 copies/ml was 94.8% and 85.3% respectively 24 and 36 months after HAART.The baseline mean CD4 count was（160.1±80）mL.The CD4 count increased gradually 0,3,6,9,12,18,24,30 and 36 months after HAART（P0.05）.The common adverse reactions were liver damage,peripherial neuritis,peripherial lipodystophy,bone marrow suppression and rash.Clinical drug resistance was found in 9 cases.Conclusion Domestic HAART has good viral responses,immunological responses,and low drug resistance for treatment-naive HIV/AIDS patients,although has much severer adverse reactions.