| 重症监护病房中革兰阴性菌耐药机制及抗菌药物应用对策 |
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| 引用本文： | 黄静霞,黄怡. 重症监护病房中革兰阴性菌耐药机制及抗菌药物应用对策[J]. 药学服务与研究, 2003, 3(4): 256-258 |
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| 作者姓名： | 黄静霞 黄怡 |
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| 作者单位： | 1. 第二军医大学长海医院麻醉科,上海,200433
2. 第二军医大学长海医院呼吸内科,上海,200433 |
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| 摘 要： | 革兰阴性菌(G^-菌)主要耐药机制有以下三方面：使药物失活、阻止药物到达作用靶、药物作用靶位改变。G菌感染用药对策包括：尽量减少抗生素不适当应用，尽早应用有针对性的敏感抗生素。本通过分析重症监护病房中G菌耐药机制及抗菌药物应用对策，为临床合理用药提供参考。
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| 关 键 词： | 耐药性 细菌 抗菌药 重症监护室 |
| 文章编号： | 1671-2838(2003)04-0256-03 |
| 修稿时间： | 2002-10-07 |
Drug-resistance mechanisms of Gram-negative bacilli in intensive care unit and the strategies for application of antimicrobial drugs |
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| HUANG Jing-Xia,HUANG Yi. Drug-resistance mechanisms of Gram-negative bacilli in intensive care unit and the strategies for application of antimicrobial drugs[J]. Pharmaceutical Care and Research, 2003, 3(4): 256-258 |
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| Authors: | HUANG Jing-Xia HUANG Yi |
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| Abstract: | Drug resistance of Gram-negative bacilli has been developed through the following three basic mechanisms: drug inactivation by producing enzymes, prevention of drug access to the target, and alternation of the drug target. Application strategies of medicine include minimizing inappropriate use of broad-spectrum antibiotics and optimal use of appropriate antibiotics as early as possible. Drug-resistance mechanisms of Gram-negative bacteria and the application of antibiotics in intensive care unit are introduced in order to give reference for clinical rational application of antibiotics. |
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| Keywords: | drug resistance bacteria antibiotic intense care unit |
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