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Pathophysiology of acute pancreatitis: Evaluation of the effect and mode of action of steroids in experimental pancreatitis in dogs
Authors:John G.N. Studley  Worthington G. Schenk
Affiliation:Buffalo, New York USA
Abstract:Three experiments were performed to evaluate the effects and hemodynamic changes brought about by steroids in experimental pancreatitis in dogs. The results show (1) a significant improval in survival in steroid-treated groups, (2) no difference in cardiac output or mean blood pressure between groups, (3) a decrease in relative pancreatic arterial blood flow in the untreated animals, and (4) an increase in arterial flow to the pancreas after steroid therapy. The experiments suggest that the reversal of reduced pancreatic flow may be important in improving the prognosis.
Keywords:Requests for reprints should be addressed to Worthington G. Schenk   Jr.   MD   Department of Surgery   State University of New York at Buffalo   462 Grider Street   Buffalo   New York 14215.
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