Persistent cellular immunity to SARS-CoV-2 infection |
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| Authors: | Gaë lle Breton,Pilar Mendoza,Thomas Hä gglö f,Thiago Y. Oliveira,Dennis Schaefer-Babajew,Christian Gaebler,Martina Turroja,Arlene Hurley,Marina Caskey,Michel C. Nussenzweig |
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| Affiliation: | 1.Laboratory of Molecular Immunology, The Rockefeller University, New York, NY;2.Hospital Program Direction, The Rockefeller University, New York, NY;3.Howard Hughes Medical Institute, Baltimore, MD |
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| Abstract: | SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen–specific memory that could contribute to rapid recall responses. Recovered individuals also show enduring alterations in relative overall numbers of CD4+ and CD8+ memory T cells, including expression of activation/exhaustion markers, and cell division. |
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