Protective action of dithiocarbamates on experimental liver damage produced by carbon tetrachloride |
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Authors: | Engelina M. den Tonkelaar M.J. van Logten |
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Affiliation: | Laboratory of Toxicology, National Institute of Public Health, Bilthoven, The Netherlands |
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Abstract: | The protective action of dithiocarbamates on CCl4-induced liver damage in rats was assessed with liver function tests (BSP retention test and SGPT). When given immediately before CCl4, all dithiocarbamates tested showed a protection against CCl4 hepatotoxicity except for zineb and some “polymer” dithiocarbamates. For zineb it appears plausible that this was caused by a delayed absorption. No protection was found when one of the dithiocarbamates studied was given 1 hr after CCl4 administration. From studies with some metabolites and related compounds it appears that only substances containing a carbon disulphide group have a protective action. Probably these compounds function as effective free radical scavengers. In addition, inhibition of microsomal liver enzyme activity and a lowering of body temperature could also be contributing factors. |
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