Nitrite intoxication: Protection with methylene blue and oxygen |
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| Authors: | Maureen H Sheehy James L Way |
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| Institution: | 1. Department of Pharmacology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99163 USA;2. College of Pharmacy, Washington State University, Pullman, Washington 99163 USA |
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| Abstract: | The lethal effects of sodium nitrite can be antagonized by the administration of various combinations of methylene blue, oxygen, and hyperbaric oxygen. The potency ratios were compared in groups of mice pretreated with methylene blue (2 or 20 mg/kg) and/or oxygen (1 ATA or 2 ATA). Hyperbaric oxygen (2 ATA) was found to be more effective than oxygen (1 ATA) or air with or without methylene blue at 2 mg/kg. When the dose of methylene blue was increased to 20 mg/kg, oxygen (1 ATA) was more effective than air, but hyperbaric oxygen was no more efficacious than oxygen (1 ATA). |
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