Interleukin‐6 polymorphism and bronchopulmonary dysplasia risk in very low‐birthweight infants |
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Authors: | Touhei Usuda Takehiro Kobayashi Seiichi Sakakibara Akira Kobayashi Takayuki Kaneko Masaki Wada Junya Onozuka Osamu Numata Katsumi Torigoe Hajime Yamazaki Takashi Sato Yoshihisa Nagayama Makoto Uchiyama |
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Affiliation: | 1. Division of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences;2. Department of Pediatrics, Nagaoka Red Cross Hospital;3. Department of Pediatrics, Niigata City General Hospital, Niigata, Japan |
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Abstract: | Background: The aim of the present study was to evaluate the role of interleukin (IL)‐6‐634 polymorphism in neonatal disorders such as bronchopulmonary dysplasia (BPD) and periventricular leukomalacia (PVL) in very low‐birthweight (VLBW) infants. Methods: This prospective cohort study included 202 infants (gestational age at birth, 23–34 weeks; birthweight, 500–1499 g). Genotypic analysis (polymerase chain reaction–restriction fragment length polymorphism) was performed with DNA extracted from whole‐blood samples. Results: Genotype distribution (66.8% CC, 28.2% CG, 5.0% GG) was similar to that in the adult Japanese population. BPD occurred in 85 infants (42.1%) among 202 VLBW infants. The duration of O2 therapy in infants with CG/GG genotypes was significantly longer than that in infants with the CC genotype (CG/GG vs CC: 40.3 ± 52.2 days vs 28.4 ± 32.6 days, P < 0.05), but the prevalence of BPD was not associated with the CG/GG genotype (CG/GG, 40.0%; CC, 46.3%, P= 0.24). Infants with CG/GG genotypes were more likely to have received postnatal corticosteroid therapy for BPD than those with the CC genotype (CG/GG vs CC: 20.9% vs 11.1%, P= 0.05). PVL occurred in six infants (3.0%). There was no significant difference in the prevalence of PVL among IL‐6‐634 polymorphisms (CG/GG, 3.0%; CC, 3.0%, P= 0.65). Conclusions: IL‐6‐634 polymorphism is associated with duration of oxygen therapy in VLBW infants. This suggests that the IL‐6‐634 polymorphism G allele is an aggravating factor of BPD. IL‐6‐634 polymorphism is not associated with PVL. |
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Keywords: | bronchopulmonary dysplasia gene polymorphism interleukin‐6 periventricular leukomalacia very low‐birthweight infant |
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