| COX-2 Survivin在大肠癌组织中的表达及意义 |
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| 引用本文： | 王芳,王翠莲,郭丽丽,王志萍.COX-2 Survivin在大肠癌组织中的表达及意义[J].长治医学院学报,2010,24(1):19-21. |
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| 作者姓名： | 王芳 王翠莲 郭丽丽 王志萍 |
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| 作者单位： | 长治医学院附属和济医院胃镜室,046000;长治医学院附属和济医院胃镜室,046000;长治医学院附属和济医院胃镜室,046000;长治医学院附属和济医院胃镜室,046000 |
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| 摘 要： | 目的：研究环氧化酶-2（COX-2）和生存素（Survivin）在大肠癌组织中的表达，探讨两者间的相互关系。方法：采用SP免疫组化技术，检测92例大肠癌及30例正常大肠组织中COX-2和Survivin的表达，并对其与临床病理参数的关系进行分析。结果：30例正常大肠组织中COX-2和Survivin的表达为阴性，92例大肠癌组织中COX-2和survivin的阳性表达率分别为60．9％和71．7％，显著高于正常大肠组织（P〈0．05），COX-2阳性表达与大肠癌淋巴结转移、临床分期相关（P〈0．05），与大肠癌大小、浸润程度、分化程度无关（P〉0．05）。Survivin阳性表达与大肠癌淋巴结转移、临床分期、分化程度相关（P〈0．05），与肿瘤大小及浸润程度无关（P〉0．05），COX-2与Survivin表达密切相关（P〈0．05）。结论：COX-2和Survivin在大肠癌组织中的表达密切相关。
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| 关 键 词： | COX-2 Survivin 大肠癌 免疫组织化学 |
The Expression and its Significance of COX-2 and Survivin in Colorectal Carcinoma Tissues |
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| Wang Fang,Wang Cuilian,Guo Lili,et al..The Expression and its Significance of COX-2 and Survivin in Colorectal Carcinoma Tissues[J].Journal of Changzhi Medical College,2010,24(1):19-21. |
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| Authors: | Wang Fang Wang Cuilian Guo Lili |
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| Institution: | Wang Fang,Wang Cuilian,Guo Lili,et al.Heji Hospital Affiliated to Changzhi Medical College |
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| Abstract: | Objective:To study the expression of COX-2 and Survivin in colorectal carcinoma.To investigate their correlation. Methods:The expression of COX-2 and Survivin in 92 cases of colorectal ccarcinoma and 30 cases of normal colorectal tissue was detected by SP immunohistochemical technique.Results: COX-2 and Survivin were negative in 30 cases of normal colorectal tissue.In 92 cases of colorectal carcinoma the positive rates of COX-2 and survivin were 71.7% and 60.87% respectively.It was significantly higher than... |
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| Keywords: | COX-2 Survivin Colorectal carcinoma SP immumohistochemical technique |
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