A review of methotrexate‐associated hepatotoxicity |
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| Authors: | Roopjeet K. Bath Navkiran K. Brar Faripour A. Forouhar George Y. Wu |
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| Affiliation: | 1. Department of Medicine, Division of Gastroenterology & Hepatology, University of Connecticut Health Center, , Farmington, Connecticut, USA;2. Department of Medicine, University of Connecticut Health Center, , Farmington, Connecticut, USA;3. Department of Anatomic Pathology, University of Connecticut Health Center, , Farmington, Connecticut, USA |
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| Abstract: | Methotrexate is effective not only in treating psoriasis and rheumatoid arthritis but also various other disorders. The use of methotrexate has been somewhat limited by concerns regarding its adverse effects, including its potential for hepatotoxicity. The purpose of this article is to provide an overview of methotrexate‐associated hepatotoxicity, including risk factors, pathogenesis and recommendations for monitoring it by US, UK and European guidelines, as well as providing a brief overview of its mechanism of action and of high‐dose methotrexate. |
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| Keywords: | methotrexate hepatotoxicity monitoring |
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