Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma |
| |
| Authors: | Cordano Pablo Lake Annette Shield Lesley Taylor G M Alexander Freda E Taylor Penelope R A White Jo Jarrett Ruth F |
| |
| Affiliation: | LRF Virus Centre, Institute of Comparative Medicine, University of Glasgow, Glasgow G61 1QH, UK. p.cordano@vet.gla.ac.uk |
| |
| Abstract: | A single nucleotide polymorphism (SNP) is present at position -174 of the human interleukin-6 gene. The risk of developing Hodgkin's lymphoma (HL) in young adults decreases with an increasing number of C alleles at this position. We analysed the effect of this SNP on incidence and outcome in HL. DNA samples from 408 cases and 349 controls were screened and analysed following stratification by age, histological subtype and Epstein-Barr virus status. Although the risk of classical HL in young adults decreased with increasing C alleles, case-control differences were not significant. An excess of G alleles was observed for nodular lymphocyte predominant HL in young adults (n = 21), which was significant. |
| |
| Keywords: | IL-6 single nucleotide polymorphism Hodgkin's lymphoma |
| 本文献已被 PubMed 等数据库收录！ |
|
