Preparation and characterization of macroporous chitosan-gelatin/beta-tricalcium phosphate composite scaffolds for bone tissue engineering |
| |
Authors: | Yin Yuji Ye Fen Cui Junfeng Zhang Fujiang Li Xiulan Yao Kangde |
| |
Affiliation: | Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, People's Republic of China. |
| |
Abstract: | A biodegradable composite scaffold was developed using beta-tricalcium phosphate (beta-TCP) with chitosan (CS) and gelatin (Gel) in the form of a hybrid polymer network (HPN) via co-crosslinking with glutaraldehyde. Various types of scaffolds were prepared by freezing and lyophilizing. These scaffolds were characterized by Fourier transform infrared, X-ray diffractometer, and scanning electron microscopy. The macroporous composite scaffolds exhibited different pore structures. Compressive properties were improved, especially compressive modulus from 3.9-10.9 MPa. Biocompatibility was evaluated subcutaneously on rabbits. A mild inflammatory response was observed over 12 weeks. The results suggest that the scaffolds can be utilized in nonloading bone regeneration. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|