COX-2 selective inhibitors and bone |
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| Authors: | Goodman S B Ma T Genovese M Lane Smith R |
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| Affiliation: | Dept Orthopaedic Surgery and Div Immunol Rheumatol, Stanford University Medical Center, Stanford, CA 94305, USA. goodbone@stanford.edu |
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| Abstract: | Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed medications for relief of pain and inflammation. Recent animal studies using models of fracture healing and bone ingrowth suggest that NSAIDs (both non-selective NSAIDs and selective COX-2 inhibitors) adversely affect these bone-related processes. The dose and time-relationships of these medications and their resulting effects on bone have not yet been fully elucidated. Furthermore, whether COX-2 inhibitors and non-selective NSAIDs lead to clinically relevant adverse effects on bone healing in humans is unknown. |
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