蕈样肉芽肿免疫表型分析及分子遗传学研究进展

 蕈样肉芽肿（MF）是最常见的原发皮肤T细胞淋巴瘤，临床上病程缓慢、迁延。MF肿瘤性T细胞最常见的免疫表型是 α/β T辅助细胞表型 (  βF1⁺、TCR-γ^-、CD3⁺、 CD4⁺、CD5⁺、CD8^-、CD45Ro⁺、TIA-1^-)，占80%左右。但仍有一部分MF免疫表型很少见，如表达细胞毒性T细胞的标记(  CD8⁺, TIA-1⁺)、表达B细胞的标记（  CD20⁺）、表达间变大细胞的标记（  CD30⁺）、等，这些少见的免疫表型很容易与其它侵袭性较高的淋巴瘤相混淆，造成误诊、误治。本文对MF的免疫表型进行分析总结，并探讨其分子遗传学研究进展。

Immunophenotypic characterization and molecular genetic advances in mycosis fungoides

Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma, which is characterized by slow evolution and protracted course. The most common immunophenotype of MF is α/β T helper cell (βF1⁺、TCR-γ^-、CD3⁺、 CD4⁺、CD5⁺、CD8^-、CD45Ro⁺、TIA-1^-)，accounting for 80%. However, there are still rare and special immunophenotypes: expression of cytotoxic markers of T cells (  CD8⁺, TIA-1⁺),expression of B cell marker (CD20⁺）,and expression of anaplastic large cell marker (CD30⁺）. These rare immunophenotypes are easily confused with other aggressive lymphomas, resulting in misdiagnosis and mistreatment. In this review paper, the immunophenotype of MF was summarized, and the research advances of molecular genetics were discussed.