Silencing SATB1 influences cell invasion,migration, proliferation,and drug resistance in nasopharyngeal carcinoma |
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| Authors: | Chun-Sheng Ye Dong-Ni Zhou Qing-Qing Yang Yan-Fei Deng |
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| Institution: | 1.Department of Otolaryngology-Head and Neck Surgery, Zhongshan Hospital, Xiamen University, Xiamen, China;2.Department of Pathology, Zhongshan Hospital, Xiamen University, Xiamen, China;3.Department of Otolaryngology-Head and Neck Surgery, Union School of Clinical Medicine, Fujian Medical University, Fuzhou, China |
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| Abstract: | Special AT rich sequence binding protein 1 (SATB1) play an important role in many cancers, but the role of SATB1 in nasopharyngeal carcinoma (NPC) is still not full understand. Immunofluorescence staining showed that SATB1 was mainly localized in the nuclei in CNE-2 cell. After successful down-regulation of SABT1 in NPC cell line CNE-2 by shRNA, compared to parental CNE-2 and control shRNA group, the capacity of the proliferation, migration, invasion and drug resistance of CNE-2 cell was reduced, which indicated that SATB1 may be involved in NPC development and progression. SATB1 may be a promising therapeutic target for nasopharyngeal carcinoma. |
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| Keywords: | Nasopharyngeal carcinoma SATB1 invasion proliferation drug resistance |
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