Swallowing dysfunction in myasthenia gravis patients examined with high-resolution manometry |
| |
| Affiliation: | 1. Department of Otolaryngology Head and Neck Surgery, Nagasaki University Graduate School of Medicine, Japan;2. Department of Otolaryngology Head and Neck Surgery, Kumamoto University Graduate School of Medicine, Japan;3. Department of Rehabilitations, Kumamoto Health Science University, Kumamoto, Japan;4. Department of Neurology, Graduate School of Medical Sciences, Kumamoto University Japan, Japan;1. Department of Bacteriology, Laboratory for Disinfection and Pathogen Elimination Studies, Northern Ireland Public Health Laboratory, Nightingale (Belfast City) Hospital, Lisburn Road, Belfast, Northern Ireland BT9 7AD, UK;2. Wellcome-Wolfson Institute For Experimental Medicine, Queen''s University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK;3. School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK;1. Department of Otolaryngology, Head and Neck Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon Ehime 791-0295, Japan;2. Department of Public Health Research, Kurashiki Clinical Research Institute, Kurashiki, Japan;1. Department of Clinical Laboratory, Yokohama Brain and Spine Center, Yokohama, Japan;2. Department of Neurology, Yokohama Brain and Spine Center, Yokohama, Japan;1. Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Largo del Pozzo, 71, 41125, Modena Italy;2. Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Verona, Piazzale Aristide Stefani, 1, 37126, Verona, Italy |
| |
| Abstract: | ObjectiveTo prospectively compare oropharyngeal swallowing dysfunction in myasthenia gravis (MG) patients presenting with difficulty in swallowing between the neutral and chin-down positions, based on the results of high-resolution manometry (HRM) examination.MethodsWe prospectively compared the HRM results of swallowing studies of seven MG patients showing difficulty in swallowing (neutral and chin-down positions) at the Department of Neurology of our institution during the period February–December 2018. The HRM assessment parameters were as follows: maximum swallowing pressure (SP) at the soft palate, meso‑hypopharynx, and upper esophageal sphincter (UES), and the duration of relaxation pressure at the UES. These parameters were compared between the two positions and their correlations with the results of neurological evaluations, such as the Quantitative Myasthenia Gravis (QMG) score (total and neck muscles alone), and grip strength, were also analyzed.ResultsIn comparison with the neutral position, in the chin-down position the maximum SP at the meso‑hypopharynx was significantly increased (p < 0.05), the maximum SP at the UES was significantly decreased (p < 0.05), and the duration of relaxing SP at the UES was significantly increased (p < 0.05). Interestingly, there were no correlations between the SP at any location and the results of the neurological evaluations.ConclusionsThe chin-down position appears useful for improving pharyngeal clearance in MG patients, by promoting increased SP at the meso‑hypopharynx, relaxing SP at the UES, and increasing the duration of relaxation pressure at the UES. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
