Evaluation of synchronous multiple primary superficial laryngo-pharyngeal cancers that were treated by endoscopic laryngo-pharyngeal surgery |
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| Institution: | 1. Department of Head and Neck Surgery, Tokyo Medical and Dental University, Tokyo, Japan;2. Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan;3. Department of Otolaryngology, Head and Neck Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan;4. Department of Otolaryngology, Head and Neck Surgery, Japanese Red Cross Musasiho Hospital, Tokyo, Japan;1. Department of Clinical Laboratory, Yokohama Brain and Spine Center, Yokohama, Japan;2. Department of Neurology, Yokohama Brain and Spine Center, Yokohama, Japan;1. Department of Otolaryngology, Head and Neck Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon Ehime 791-0295, Japan;2. Department of Public Health Research, Kurashiki Clinical Research Institute, Kurashiki, Japan;1. Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Largo del Pozzo, 71, 41125, Modena Italy;2. Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Verona, Piazzale Aristide Stefani, 1, 37126, Verona, Italy;1. Department of Otolaryngology, Ebara Hospital, Tokyo Metropolitan Health and Hospitals Corporation, Japan;2. Japan Otorhinolaryngologist Association, Japan;3. Committee of Community healthcare, The Oto-Rhino-Laryngological Society of Japan, Japan;1. Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan;2. Department of Otorhinolaryngology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan;3. Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan;4. Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan |
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| Abstract: | Objectivendoscopic laryngopharyngeal surgery (ELPS) is a useful surgery for superficial cancers of the head and neck region, but it has not yet been well evaluated for synchronous multiple primary cancers (multiple primaries). The purpose of this study was to clarify the safety and usefulness of ELPS for patients with multiple superficial primary cancers in the head and neck region.Methodsrom December 2009 to December 2016, 145patients with superficial head and neck cancers underwent ELPS. The patients were divided into two groups; a group consisting of patients with a single primary cancer (single primary) and another group consisting of patients with synchronous multiple primaries, and the incidences of postoperative complications and lymph node metastasis were retrospectively compared between the two groups.Resultsf the 145 patients, 107 had a single primary cancer and 38 had multiple primaries. There was no significant difference in the age, sex, or rate of intraepithelial cancer between the two groups. Postoperative complications included dysphagia in 6 (5.6%) patients with a single primary and 2 (5.3%) patients with multiple primaries. One patient with multiple primaries required gastrostomy because of aspiration pneumonia. In addition, the following complications were also observed. Laryngeal paralysis occurred in 2 (1.9%) patients with a single primary, and 1 (2.6%) patient with multiple primaries; tracheostomy because of postoperative bleeding in 1 (0.9%) patient with a single primary; infection occurred in 2 (5.3%) patients with multiple primaries. Postoperative lymph node metastasis was found in 7 (6.5%) patients with a single primary and 6 (15.8%) patients with multiple primaries. Lymphatic invasion of the primary cancer was noted in 3 (2.8%) patients with a single primary and 5 (13.2%) patients with multiple primaries, being significantly higher in the latter group.ConclusionELPS is also a safe surgery for patients with multiple primaries. However, the incidence of lymphatic invasion of the primary cancer was significantly higher in patients with multiple primaries. |
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