Novel Betacoronavirus in Dromedaries of the Middle East, 2013 |
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| Authors: | Patrick C.Y. Woo Susanna K.P. Lau Ulrich Wernery Emily Y.M. Wong Alan K.L. Tsang Bobby Johnson Cyril C.Y. Yip Candy C.Y. Lau Saritha Sivakumar Jian-Piao Cai Rachel Y.Y. Fan Kwok-Hung Chan Ringu Mareena Kwok-Yung Yuen |
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| Affiliation: | The University of Hong Kong, Hong Kong, China (P.C.Y. Woo, S.K.P. Lau, E.Y.M. Wong, A.K.L. Tsang, C.C.Y. Yip, C.C.Y. Lau, J.-P. Cai, R.Y.Y. Fan, K.H. Chan, K.-Y. Yuen); ;Central Veterinary Research Laboratory, Dubai, United Arab Emirates (U. Wernery, B. Johnson, S. Sivakumar, R. Mareena) |
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| Abstract: | In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAE-HKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans. |
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| Keywords: | coronavirus dromedary camel Middle East betacoronavirus dromedaries camel coronavirus dromedary coronavirus dromedary camel coronavirus UAE-HKU23 DcCoVUAE-HKU23 DcCoV viruses United Arab Emirates Dubai Middle East respiratory syndrome coronavirus MERS-CoV zoonoses |
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