Outcome after surgical resection of multiple recurrent retroperitoneal soft tissue sarcoma |
| |
| Affiliation: | 1. Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany;2. Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany;3. Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany;4. Department of Translational Oncology, National Center for Tumor Diseases Heidelberg and German Cancer Research Center, Heidelberg, Germany;1. Department of Surgery, Catharina Hospital Eindhoven, the Netherlands;2. Department of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, the Netherlands;3. GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands;4. Department of Internal Medicine, Catharina Hospital Eindhoven, the Netherlands;5. Department of Surgery, Maastricht University Medical Center +, Maastricht, the Netherlands;6. Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, Enschede, the Netherlands;7. Department of Radiotherapy, Catharina Hospital Eindhoven, the Netherlands;1. Breast Unit, Cancer Center, IRCCS Clinical Institute Humanitas, Rozzano (MI), Italy;2. Anatomia Patologica Ospedaliera, IRCCS Ospedale Policlinico San Martino, Genova, Italy;3. Epidemiologia Clinica, IRCCS Ospedale Policlinico San Martino, Genova, Italy;4. Breast Unit, Ospedale Villa Scassi, Genova, Italy |
| |
| Abstract: | IntroductionLocal recurrences (LR) and distant metastases (DM) are common in retroperitoneal soft tissue sarcoma (RPS). Longer time to recurrence and resection of the recurrent lesion have been identified as beneficial prognostic factors for overall survival (OS) upon first tumor relapse. However, prognostic factors concerning OS upon subsequent recurrences are scarcely defined. In this study, we aimed to identify prognostic factors for post-relapse outcome in multiple recurrent RPS.MethodsPatients undergoing resection of primary and recurrent RPS at the University Hospital Heidelberg were retrospectively analyzed. Multivariable Cox regression analyses were performed to identify predictors of overall, LR- and DM-free survival. Subgroup analyses were performed for liposarcoma and leiomyosarcoma patients.Results201 patients with primary disease, 101 patients with first, 66 patients with second and 43 patients with third LR as well as 75 patients with DM were analyzed. More than 12 months to recurrence and resection of recurrence were associated with improved OS after resection of first and second LR (5-year OS for first/second LR; resection: 64%/62%, no resection: 20%/46%). Gross macroscopic incomplete resection of first (p < 0.001), second (p = 0.001), and third recurrences (p < 0.001) was an independent prognostic factor for poor OS.ConclusionDevelopment of LR and DM is frequent in RPS. Once a tumor relapsed, patients benefit from tumor resection not only in case of first, but also in case of subsequent recurrences. |
| |
| Keywords: | Retroperitoneal soft tissue sarcoma Recurrence Overall survival Resection Surgery |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
