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Utility of a modified age-adjusted Charlson Comorbidity Index in predicting cause-specific survival among patients with gastric cancer |
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| Institution: | 1. Department of Surgery, Catharina Hospital Eindhoven, the Netherlands;2. Department of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, the Netherlands;3. GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands;4. Department of Internal Medicine, Catharina Hospital Eindhoven, the Netherlands;5. Department of Surgery, Maastricht University Medical Center +, Maastricht, the Netherlands;6. Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, Enschede, the Netherlands;7. Department of Radiotherapy, Catharina Hospital Eindhoven, the Netherlands;1. Croydon University Hospital, Croydon, UK;2. Royal Marsden NHS Foundation Trust, Sutton, UK;3. Imperial College, London, UK;4. Pelican Cancer Foundation, Basingstoke, UK;5. Basingstoke Hospital, Hampshire Hospitals Foundation Trust, Basingstoke, UK;1. Breast Unit, Cancer Center, IRCCS Clinical Institute Humanitas, Rozzano (MI), Italy;2. Anatomia Patologica Ospedaliera, IRCCS Ospedale Policlinico San Martino, Genova, Italy;3. Epidemiologia Clinica, IRCCS Ospedale Policlinico San Martino, Genova, Italy;4. Breast Unit, Ospedale Villa Scassi, Genova, Italy;1. Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University Halle-Wittenberg, University Medical Center Halle, Halle, Germany;2. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany;3. Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland;4. Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany;5. Institute for Pathology, Industriestr. 11c, 67063, Ludwigshafen, Germany |
| Abstract: | IntroductionThe current study aimed to evaluate the ability of a modified version of the age-adjusted Charlson Comorbidity Index (mACCI) in predicting cause-specific survival (CSS) among patients with gastric cancer who underwent curative gastrectomy and compared it with the conventional ACCI.Materials and methodsPatients who underwent gastrectomy for gastric cancer from 2007 to 2016 (n = 2885) were included. A mACCI was established by excluding scores for other malignancies, such as other cancers, leukemia, and lymphoma. After determining the optimal cutoff ACCI and mACCI values for CSS, clinicopathological factors and survival outcomes were assessed according to the ACCI and mACCI.ResultsBoth ACCI and mACCI were identified as independent prognostic factors for overall survival (p < 0.001 and p < 0.001, respectively). However, only mACCI was identified as an independent prognostic factor for CSS (p < 0.001). The present study suggested that mACCI was a better indicator of CSS in patients with gastric cancer who underwent curative gastrectomy than ACCI.ConclusionOur findings showed that the mACCI was a strong predictor of CSS in patients with gastric cancer who underwent curative gastrectomy. We believe that the mACCI will become a novel marker that would guide treatment decisions for patients with gastric cancer suffering from comorbidities. |
| Keywords: | Gastric cancer Modified age-adjusted Charlson comorbidity index Cause-specific survival ACCI"} {"#name":"keyword" "$":{"id":"kwrd0030"} "$$":[{"#name":"text" "_":"Adjusted Charlson Comorbidity Index CCI"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"Charlson Comorbidity Index CSS"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"Cause-specific survival IQR"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "_":"Interquartile range OS"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"Overall survival PIIC"} {"#name":"keyword" "$":{"id":"kwrd0080"} "$$":[{"#name":"text" "_":"Postoperative intra-abdominal infectious complications PS"} {"#name":"keyword" "$":{"id":"kwrd0090"} "$$":[{"#name":"text" "_":"Performance status |
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