|
|||||
|
|
| 脑干损伤中单胺递质变化的意义 | |
| 引用本文： | 房向阳,吕晓萍,杨艳红.脑干损伤中单胺递质变化的意义[J].中风与神经疾病杂志,2001,18(1):27-28. |
| 作者姓名： | 房向阳 吕晓萍 杨艳红 |
| 作者单位： | 1. 吉林大学中日联谊医院神经外科, 2. 吉林大学中日联谊医院检验科, 3. 吉林省蛟河市医院检验科, |
| 摘 要： | 目的 探讨脑组织在创伤、出血、缺血等病理情况下单胺递质的变化及其意义。方法 选取原发脑干损伤患者，伤后6-12h内采集患者肘静脉血及腰穿取脑脊液，之后1周内每天采集1次，1周后每周采集2次，到清醒或死亡时止，以Miller's的荧光分光法检测脑干损伤的患者血液及脑脊液中单胺递质-5-羟色胺（5-HT）、去甲肾上腺素（ＮＥ）、多巴胺（DA），分析脑干损伤程度与单胺递质浓度变化的关系。结果 急性颅脑创伤后，患者血浆和脑脊液中NE、DA含量明显升高，伤后病情逐渐好转者第3天达到高峰，然后逐渐下降至正常水平，死亡病例首次值明显升高，下降缓慢，但伤情极重者升高后迅速下降。结论 单胺递质浓度变化与脑干损伤程度呈正相关，与预后关系密切。 |
| 关 键 词： | 颅脑损伤 脑干 神经递质 单胺递质 |
| 文章编号： | 1003-2754(2001)01-0027-02 |
| 修稿时间： | 2000年5月31日 |
Changes of monoamine neurotransmitter in brain-stem injury |
|
| FANG Xiang-yang,LU Xiao-ping,YANG Yan-hong.Changes of monoamine neurotransmitter in brain-stem injury[J].Journal of Apoplexy and Nervous Diseases,2001,18(1):27-28. | |
| Authors: | FANG Xiang-yang LU Xiao-ping YANG Yan-hong |
| Abstract: | Objective To study monoamine neurotransmitter obviously changes in cerebral damage、ischemia and hemorrhage. Methods We reported the changes by means of flurospectrophotometry after brain-stem injury on selected patients , and then analyzed the relationship between the changes and the prognosis. Results It showed that 5-HT、 NE、 DA increased apparently after brain-stem injury , then drop to the normal level as fast as reinvigoration . The exception to this rule is for severe brain-stem injury in which neurotransmitter drops fastly soon after increasing. Conclusion It suggests that we can predict the prognosis by the changes of monoamine neurotransmitter. |
| Keywords: | |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |