| 99Tcm-ECD SPECT非侵入性的定量测定平均CBFl和rCBF理论及其应用研究 |
| |
| 引用本文： | 张凯军,张永学,安锐,高再荣,曹国祥,黄代娟. 99Tcm-ECD SPECT非侵入性的定量测定平均CBFl和rCBF理论及其应用研究[J]. 中国医学影像技术, 2004, 20(5): 771-775 |
| |
| 作者姓名： | 张凯军 张永学 安锐 高再荣 曹国祥 黄代娟 |
| |
| 作者单位： | 张凯军（华中科技大学同济医学院附属协和医院核医学科,湖北武汉,430022）;张永学（华中科技大学同济医学院附属协和医院核医学科,湖北武汉,430022）;安锐（华中科技大学同济医学院附属协和医院核医学科,湖北武汉,430022）;高再荣（华中科技大学同济医学院附属协和医院核医学科,湖北武汉,430022）;曹国祥（华中科技大学同济医学院附属协和医院核医学科,湖北武汉,430022）;黄代娟（华中科技大学同济医学院附属协和医院核医学科,湖北武汉,430022） |
| |
| 摘 要： | 目的定量评价大脑及局部的平均脑血流量,应用
|
| 关 键 词： | ^99Tc^m-ECD 局部脑血流显像 SPECT 定量 |
| 文章编号： | 1003-3289(2004)05-0771-05 |
| 修稿时间： | 2003-09-14 |
Noninvasive quantitative measurements of mean regional cerebral blood flow using 99Tcm-ethyl cysteinate dimer |
| |
| ZHANG Kai-jun,ZHANG Yong-xue,AN Rui,GAO Zai-rong,CAO Guo-xiang and HUANG Dai-juan. Noninvasive quantitative measurements of mean regional cerebral blood flow using 99Tcm-ethyl cysteinate dimer[J]. Chinese Journal of Medical Imaging Technology, 2004, 20(5): 771-775 |
| |
| Authors: | ZHANG Kai-jun ZHANG Yong-xue AN Rui GAO Zai-rong CAO Guo-xiang HUANG Dai-juan |
| |
| Affiliation: | Department of Nuclear Medicine, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022, China;Department of Nuclear Medicine, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022, China;Department of Nuclear Medicine, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022, China;Department of Nuclear Medicine, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022, China;Department of Nuclear Medicine, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022, China;Department of Nuclear Medicine, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022, China |
| |
| Abstract: | Objective A non-invasive, simple method for the quantitative evaluation and measurement of mean cerebral blood flow (mCBF) is presented using radionuclide brain imaging with technetium-99m-ethyl cysteinate dimer (99Tcm-ECD). Methods We firstly obtained the brain perfusion index (BPI), then described a further development of this method to measure regional mCBF(mrCBF) in conjunction with SPECT and empirical equation. This method of measuring mCBF from SPECT was validated in 20 normal control subjects and 27 patients with cerebrovascular diseases and the reproducibility of the method was investigated. Results The results showed a high degree of reproducibility of the method. The mean whole brain BPI of cerebrovascular patients was significantly lower than that of normal controls (P<0.01). Simultaneously the mean CBF of cerebrovascular patients was significantly lower than that of normal controls (P<0.01). The mrCBF between in normal subjects and results reported by data had no significant difference. Conclusion The quantitative method of graphical analysis permits the routine measurement of mrCBF from 99Tcm-ECD SPECT tomograms of perfusion. The method is non-invasive (without any blood sampling) and has a prospective application and practically clinical value. |
| |
| Keywords: | 99Tcm-ECD rCBF SPECT Quantitative |
|
| 点击此处可从《中国医学影像技术》浏览原始摘要信息 |
|
点击此处可从《中国医学影像技术》下载全文 |
|
