达格列净对2型糖尿病合并高血压患者醛固酮/肾素浓度比值的影响

目的:探讨达格列净对2型糖尿病（T2DM）合并高血压患者醛固酮/肾素浓度比值（ARR）的影响。方法:选取2019年9月至2020年12月就诊于北京怀柔医院内分泌科的T2DM合并高血压患者。测量并记录患者治疗前体重、空腹血糖（FPG）、糖化血红蛋白（HbA 1c）、尿酸、血浆肾素浓度、醛固酮水平等指标，并计算...

Effect of dapagliflozin on aldosterone to renin ratio in patients with type 2 diabetes mellitus complicated with hypertension

Objective To investigate the effect of dapagliflozin on aldosterone to renin ratio(ARR)in patients with type 2 diabetes mellitus(T2DM)complicated with hypertension.Methods Patients with T2DM and hypertension who were admitted to the Department of Endocrinology,Beijing Huairou Hospital from September 2019 to December 2020 were enrolled.Body weight,fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),uric acid,plasma renin concentration,aldosterone level and other indicators were measured and recorded before treatment,and ARR was calculated.Patients were treated with dapagliflozin for 12 weeks,and hematologic indicators were collected again while ARR was also calculated.Paired t test or Mann-Whitney U test were used to compare the ARR and related indexes before and after treatment of dapagliflozin.Results A total of 20 patients were enrolled.ARR before and after treatment were 0.86(0.73,1.20)and 0.95(0.72,1.32),respectively.However,there was no significant difference between them(Z=1.12,P=0.263).After 12 weeks of dapagliflozin,FPG(Z=-3.62,P<0.001),HbA1c(Z=-3.76,P<0.001),body weight(Z=-3.19,P=0.001)and uric acid(Z=-2.71,P=0.014)decreased significantly compared with baseline.Conclusions Dapagliflozin has no effect on ARR in patients with T2DM complicated with hypertension,but it has good effects on reducing FPG,uric acid and weight loss.